Chordate Medical receives rhinitis-order from private hospital chain in Jeddah

Chordate Medical has received an initial order for equipment and supplies to the treatment method K.O.S for chronic rhinitis via the company's distributor in Saudi Arabia, Janin Medical. The customer is the private healthcare company Nahdi Care Clinics, with four hospitals located in the country's second largest city, Jeddah.

“The healthcare company has evaluated K.O.S for some time and treated approximately 30 patients. They have now placed a small initial order worth around SEK 120,000 for one of their hospitals, and we expect that they will shortly place orders for two more of their four care facilities. In most cases, the treatments at NadiCare are reimbursed by insurance from the private healthcare insurance company BUPA Arabia. One can roughly expect that a patient in Saudi Arabia means an average annual revenue from end-user sales stage of around SEK 10,000”, says Anders Weilandt, CEO of Chordate.

Three publicly owned hospitals in Jeddah, Makkah and Dammam have also evaluated K.O.S and Janin Medical expects incoming orders from all three. In addition to incoming orders for K.O.S for rhinitis, Janin Medical is also driving the process of registering a market authorization for K.O.S for chronic migraine, where the registration process will take at least two months.

“Since we’ll receive more and more orders for the rhinitis treatment, the road to a market permit for the migraine indication is shorter and less difficult than before.”

The Saudi Food and Drug Authority (SFDA) has previously approved Janin Medical as Chordate's new authorized representative in the country, and transfer of the market authorization for the rhinitis treatment to Janin.

Chronic rhinitis in Saudi Arabia

The prevalence of chronic rhinitis is high in Saudi Arabia due to air pollution in major cities, high incidence of mites and mold spores, combined with constant alternation between high outdoor temperatures and cold indoor environments. Chronic rhinitis is considered a major health problem that has been given a lot of attention. The overall picture is that treatment should be given 2-3 times more often than in Northern Europe due to the low air quality. Excessive long-term use of nasal spray is also very common and is seen as a very urgent problem to overcome, even here the K.O.S treatment is seen as a valuable therapeutic tool.

Interview: specialist in neurology dr. Emilia Tauriala on Chordate’s migraine treatment

Dr. Emilia Tauriala is a specialist in neurology, Chief Medical Officer at Terveystalo – one of Finland's largest private healthcare companies, and one of the trial leaders in Chordate Medical's study PM-007 in Finland. In an interview with Biostock, she talks about the study work, the benefits of K.O.S and the great need for new treatments for chronic migraine.

”The headache days were significantly reduced when comparing the real internasal stimulation to sham stimulation. The side effect profile is very different. K.O.S mostly gives side effects during those 20 minutes when you receive the treatment, but the rest of the week you’re “free to go” so to speak. Currently, available treatments for migraine prevention include medication mostly. So, we have blood pressure medication, anti-depressants, and anti-epileptic drugs available for most patients. While they can be effective for some individuals, they’re not always successful in reducing migraine days or the severity of the attacks, and they may also have unwanted side effects. It is actually quite common that the side effects prevent use of those treatments”, says Dr. Emilia Tauriala in the interview.

Watch the interview with Dr. Emilia Tauriala, Specialist in neurology and CMO at Terveystalo.

The primary final results from Chordate Medical's PM-007 study will be presented at the American Headache Society's Scientific Meeting in mid-June. The results show that K.O.S has a significant effect in the preventive treatment of chronic migraine. Chordate CEO Anders Weilandt has previously commented on the study results:

"The fact that AHS invites the researchers in the study to present the study results in a lecture format confirms the importance of the study results, which show that K.O.S has a significant clear effect for the preventive treatment of chronic migraine. We see the customary publication of the abstract as very positive because it will contribute to the knowledge about the treatment method spreading faster both in the USA and the rest of the world," says Chordate CEO Anders Weilandt in a Biostock article.

Read more about The migraine market in Finland and Chordate’s outlook

Chordate announces that the American Headache Society has accepted a presentation of the final results of the PM007 study at the AHS-congress in June 2023

Chordate Medical Holding AB (publ.) ("Chordate" or "the Company") (ticker: CMH) would like to inform the market that the primary results from the migraine study PM007 – Kinetic Oscillation Stimulation for the treatment of chronic migraine – a subgroup analysis of a randomised controlled clinical trial – have now been published in the form of an abstract on the American Headache Society's (AHS) website. The results confirm the abstract with subgroup results from the German part of PM007 presented at the Migraine Trust International Symposium 2022 London in September last year. The final results do not differ significantly from the results already reported from the subgroup analysis.

– The fact that AHS invites the researchers in the study to present the study results in a lecture format confirms the importance of the study results, which show that K.O.S has a significant clear effect for the preventive treatment of chronic migraine. We see the customary publication of the abstract as very positive because it will contribute to the knowledge about the treatment method spreading faster both in the USA and the rest of the world. As a sponsor of a study, we have no influence over, nor control of, such occurrence, says Anders Weilandt, CEO of Chordate.

The abstract reports the analysis of a selection of primary endpoints from all 132 patients in the study, where the 67 patients who received active K.O.S treatment showed a significant reduction in the number of monthly headache days (MHD) with moderate to severe intensity from baseline, compared to the 65 patients who received the sham treatment. The difference demonstrated by the least squares means (LSQ) in ANCOVA analysis between the 4-week baseline period and treatment week 3-6 was -2.23 MHD (CI95% =[-3.95; -0.51], p=0.0132). The results from the 4-week follow-up period – after completing six weeks of stimulation – showed a reduction of LSQ by -2.68 MHD (CI95% =[-4.32; -1.04], p=0.0014), thereby showing a sustained improvement during this observation period. The treatment was well-tolerated with no severe adverse events.

The authors conclude that: " The findings of the randomized, sham-controlled clinical trial show that intranasal K.O.S is an effective and safe option for the preventive treatment of chronic migraine. The non-pharmacological nature of the treatment option positions K.O.S as a valuable addition to the current therapeutic portfolio for the management of chronic migraine as beyond having a solid and sustained treatment effect, it stands out from other preventive treatments by its favourable side effect profile."

Chordate informed about the subgroup results from the clinical study PM007 in September 2022.

Agenda and more information about the AHS annual scientific meeting.

AHS is an American professional society of researchers and physicians dedicated to the study and treatment of headache and facial pain. The Society's goal is to promote the exchange of information and ideas about the causes and treatment of headache and related painful disorders. AHS's activities include a scientific annual meeting, a comprehensive headache symposium, regional symposia for neurologists and family physicians, publication of the journal Headache, and sponsorship of the American Migraine Foundation.

About PM007

The randomized, sham/placebo-controlled, double-blind multicenter study was conducted at five neurological clinics in Germany and four in Finland. The study included 132 patients and was designed to evaluate the effectiveness and safety of K.O.S treatment, with the primary efficacy endpoint being to detect the average change from baseline (4-week screening period, 4-week follow-up period) of monthly headache days with moderate to severe intensity, after weekly treatments for six weeks. Fifty percent of the patients received active K.O.S treatment from the study equipment S211, while the other half of the patients received a validated sham/placebo treatment from the same equipment. The study included patients with the diagnosis of chronic migraine (15 days/month with headache, of which >8 days with migraine) and was completed in early August 2022.

Notice to the Annual General Meeting in Chordate Medical Holding AB (publ)

The shareholders in Chordate Medical Holding AB (publ), 556962-6319, are hereby given notice of the annual general meeting to be held on Thursday, May 11, 2023, at 15:00 at the company’s premises, Regus, Kistagången 20 B in Kista, Sweden.

Registration and notification
Shareholders who wish to participate at the general meeting must

  • be recorded in the share register kept by Euroclear Sweden AB on Wednesday, May 3, 2023, and
  • give notice of their intention to participate at the general meeting no later than Friday, May 5, 2023 by post to Chordate Medical Holding AB (publ), c/o Regus, Kistagången 20 B, 164 40 Kista (please mark the envelope ”AGM Chordate”), by telephone to 08-400 115 46 or by e-mail to niklas.lindecrantz@chordate.com

For shareholders who have their shares registered through a bank or other nominee, the following applies in order to be entitled to participate in the general meeting. In addition to giving notice of participation to the general meeting, such shareholder must re- register its shares in its own name so that the shareholder is registered in the share register kept by Euroclear Sweden AB as of the record date on May 3, 2023. Such registration may be temporary (so-called voting rights registration). Shareholders who wish to register their shares in their own names must, in accordance with the respective nominee´s routines, request that the nominee makes such registration. Voting rights registration that have been requested by the shareholder at such time that the registration has been completed by the nominee no later than on May 5, 2023, will be taken into account in the preparation of the share register.

Power of attorney
If a shareholder wishes to attend the general meeting by proxy, a written and dated power of attorney signed by the shareholder in original copy must be sent by post to Chordate Medical Holding AB (publ), c/o Regus, Kistagången 20 B, 164 40 Kista. A proxy form is available on the company's website www.chordate.com. If the shareholder is a legal person, a certificate of registration or other authorization document must be attached to the form.

Agenda for the general meeting
1. Opening of the general meeting
2. Election of chairman at the general meeting
3. Preparation and approval of the voting list
4. Election of one or two persons who shall approve the minutes of the general meeting
5. Determination of whether the meeting has been duly convened
6. Approval of the agenda
7. Presentation of the annual report and the auditor’s report as well as the consolidated financial statement and the auditor’s report for the group
8. Presentation by the chairman of the board and the CEO
9. Resolution on
    a. the adoption of the income statement and the balance sheet as well as the consolidated income statement and the consolidated balance sheet
    b. the dispositions in respect of the company’s profit and loss pursuant to the adopted balance sheet
    c. discharge from liability of the directors and the CEO
10. Determination of the number of directors, deputy directors, auditors and deputy auditors
11. Determination of the fees to the board of directors and the auditor
12. Election of the board of directors and auditors
13. Proposal on an authorization for the board of directors to resolve on issuances
14. Proposal on an incentive program to the management
15. Proposal on an incentive program to the board of directors
16. Closing of the meeting

Proposed resolutions

Item 2 – Election of chairman at the general meeting
The nomination committee proposes that the chairman of the board, Henrik Rammer, is elected as chairman at the general meeting.

Item 9 b – Resolution on the dispositions in respect of the company’s profit and loss pursuant to the adopted balance sheet
The board of directors proposes that no dividend shall be distributed for the financial year 2022 and that the company’s result shall be carried forward in the new accounts.

Item 10 – Determination of the number of directors, deputy directors, auditors and deputy auditors
The nomination committee proposes that the board of directors, for the period running until the end of the next annual general meeting, shall be composed of five directors with no deputy directors and that one registered accounting firm is elected as auditor.

Item 11 – Determination of the fees to the board of directors and the auditor
The nomination committee proposes that fees to the board of directors, for the period running until the end of the next annual general meeting, shall amount to a total of SEK 620,000 with the following distribution: SEK 180,000 to the chairman of the board, SEK 140,000 to the vice chairman of the board and SEK 100,000 to each of the other members of the board who are not employed by the company.

The nomination committee proposes that the fee to the auditor, for the period running until the end of the next annual general meeting, shall be paid as incurred on approved accounts.

Item 12 – Election of the board of directors and auditors
The nomination committee proposes re-election of the members of the board of directors Henrik Rammer, Tommy Hedberg, Caroline Lundgren Brandberg and Gunilla Lundmark for the period running until the end of the next annual general meeting.

Furthermore, the nomination committee proposes election of Otto Skolling as a new vice chairman of the board of directors for the period running until the end of the next annual general meeting.

Furthermore, the nomination committee proposes re-election of Henrik Rammer as the chairman of the board of directors for the period running until the end of the next annual general meeting.

Furthermore, the nomination committee proposes re-election of Öhrlings PricewaterhouseCoopers AB as auditor for the period running until the end of the next annual general meeting. Öhrlings PricewaterhouseCoopers AB has announced that the authorized public accountant, Henrik Boman, will be the responsible auditor.

Item 13 – Proposal regarding authorization for the board of directors to resolve on issuances
The board of directors proposes that the general meeting authorizes the board of directors, on one or more occasions, until the next annual general meeting, with or without preferential rights for the shareholders, to resolve upon issue of shares, convertibles and/or warrants. Such new issue resolutions may include provisions of payment in cash and/or payment by way of contribution of non-cash consideration or by set-off of a claim or that subscription shall be subject to other conditions. The terms and conditions for the issue shall be customary to market practice with the possibility to a customary issue discount and shares, warrants and/or convertibles may be issued up to a volume corresponding to in total not more than 40 000 000 shares.

The board of directors or a person appointed by the board of directors shall be authorized to make any minor adjustments required to register the resolution with the Swedish Companies Registration Office.

A resolution in accordance with this item 13 is only valid if supported by shareholders holding not less than two thirds (2/3) of the votes cast as well as the shares represented at the general meeting.

Item 14 – Proposal on an incentive program to the management
The Board of Directors of Chordate Medical Holding AB (publ) (the ”Company”) proposes that the general meeting pass a resolution on the implementation of a long-term incentive program 2023 (”LTIP 2023:1”). The proposal is divided into the following items.

A. Resolution regarding issue and approval of transfer of warrants, series 2023/2025:1
B. Other matters in relation to LTIP 2023:1

A. Issue of warrants, series 2023/2025:1

The Board of Directors of the Company proposes that the general meeting resolve to carry out a private placement in respect of not more than 4,000,000 warrants of series 2023/2025:1, entailing an increase in the share capital of not more than SEK 1,000,000 if the private placement is fully taken up.

1. The resolution according to the above shall otherwise be governed by the following terms and conditions

1.1 The right to subscribe for the warrants, with derogation from the shareholders’ pre- emption rights, shall vest in the Company, with right and obligation to transfer the warrants to employees and consultants in the Company and its subsidiaries in accordance with below.

No oversubscription is allowed.

1.2 The reason for the derogation from the shareholders’ pre-emption rights is to implement an incentive program through which employees and consultants in the Company and its subsidiaries shall be able to become long-term owners and participate in and work for a positive growth of value of the Company’s share for the period that the program covers, and to ensure that the Company and its subsidiaries can keep and recruit qualified and motivated personnel.

1.3 The warrants shall be issued at no consideration.

1.4 Subscription for the warrants shall take place on the same day as the date of the resolution to issue warrants. The Board of Directors shall be entitled to extend the subscription period.

1.5 Each warrant entitles the holder to subscribe for one new share in the Company.

1.6 The warrants may be exercised for subscription of new shares during the period commencing on November 1, 2025, up to and including November 30, 2025.

1.7 The subscription price per share shall correspond to 150 percent of the volume- weighted average price according to Nasdaq First North Growth Market’s official price list for the share during the ten trading days immediately preceding the Annual General Meeting.

1.8 Any share premium shall be transferred to the unrestricted premium reserve.

1.9 The shares subscribed for based on the warrants shall carry a right to participate in dividends for the first time on the next record date for dividends, which occurs after subscription is completed.

1.10 Other terms and conditions according to the complete terms and conditions for series 2023/2025:1.

2. Approval of transfer of warrants, series 2023/2025:1

2.1 The Board of Directors proposes that the general meeting approves the Company’s transfer of warrants of series 2023/2025:1 in accordance with the following.

2.2 The right to acquire warrants from the Company shall vest in three categories of participants (the ”Participants”) in accordance with the table below.

Category Number of
Participants
Number of warrants
per Participant
Total number of
warrants
CEO Max. 1 Max. 2,000,000 Max. 2,000,000
Senior executives Max. 2 Max. 750,000 Max. 1,500,000
Consultants Max. 2 Max. 250,000 Max. 500,000

2.3 The warrants of series 2023/2025:1 shall be transferred on market terms at a price (premium) based on an estimated market value of the warrants that has been calculated by an independent valuation institute using the Black & Scholes valuation model.

2.4 The value for warrants of series 2023/2025:1 has, during March 2023, preliminary been calculated to SEK 0.05 per warrant based on a share price of SEK 0.53, a subscription price per share of SEK 0.80, a term of approximately 2.68 years, a risk-free interest rate of 2.8 percent and a volatility of 32 percent.

2.5 The final valuation of the warrants of series 2023/2025:1 takes place in connection with the Participants' acquisition of the warrants and will be based on market conditions at that time.

2.6 Transfer to Participants requires that the warrants can be legally acquired and that, in the Board of Director’s opinion, such acquisition can take place using a reasonable amount of administrative and financial resources. Transfer to each Participant assume that such Participant enters into an agreement regarding, among other things, right of first refusal with the Company.

2.7 Application for acquisition of warrants shall take place on May 18, 2023. The Board of Directors is authorized to extend the application period.

2.8 Payment for warrants that are acquired must be made no later than on May 18, 2023. The board has the right to extend the time for payment.

2.9 The Company reserves the right to repurchase warrants if the Participant’s employment with or assignment for the Company or its subsidiaries ceases or if the Participant in turn wishes to transfer warrants. The warrants shall otherwise be governed by market terms.

2.10 Warrants held by the Company that are not transferred to Participants or that are repurchased from Participants, may be cancelled by the Company through a decision by the Board of Directors. The cancellation shall be notified to the Swedish Companies Registration Office.

B. Other matters in relation to LTIP 2023:1

1.1 Effects on key figures and costs
The Company’s earnings per share will not be affected by the issue, since the warrants’ strike price exceeds the current market value of the shares at the time of

the issue. The Company’s future earnings per share may be affected by the potential dilutive effect of the warrants in the event the Company reports a positive result and the strike price is lower than the market value. The warrants will be transferred at market value, which means that no taxable benefit value will arise and thus no social fees for the Company. In addition, the warrant program will give rise to certain limited costs in the form of external consulting fees and administration of the warrant program.

1.2 Dilution of existing shares and votes
Based on the number of shares and votes outstanding in the Company, LTIP 2023:1 implies, upon exercise of all 4,000,000 warrants, a full dilution corresponding to approximately 1.69 percent of the total number of shares and votes outstanding in the Company on a fully diluted basis, however, subject to the recalculation of the number of shares that each warrant entitles to subscribe for that may occur as a result of certain issues etc.

Exercise of all warrants within the framework of all outstanding and proposed incentive programs in the Company would correspond to a aggregated dilution of approximately 4.52 percent of the total numbers of shares and votes in the Company on a fully diluted basis, however, subject to the recalculation of the number of shares that each warrant entitles to subscribe for that may occur as a result of certain issues etc.

1.3 Calculation of the market value
The market value has, during March 2023, preliminary been established based on a calculated market value for the warrants, applying the Black & Scholes valuation model calculated by Mazars Financial Advisory. The preliminary calculated market value is set out above in item A.2.4.

1.4 Other share-related incentive programs
In addition to the proposed incentive program for the board of directors set out under item 15 below, the Company’s share-related incentive programs are described on pages 25 and 29 in the company’s annual report.

1.5 Authorizations for the Board of Directors
The General Meeting authorizes the Board of Directors to execute the resolution under item A.2. above. In addition, the Board of Directors, or a person appointed by the Board of Directors, shall be authorized to make minor adjustments to the resolutions above that may be necessary in connection with the registration with the Swedish Companies Registration Office and Euroclear Sweden AB, respectively.

1.6 The background and rationale for the proposal
The Board of Directors wishes to implement an incentive program through which employees and consultants in the Company and its subsidiaries shall be able to become long-term owners and participate in and work for a positive growth of value of the Company’s share for the period that the program covers, and to ensure that the Company and its subsidiaries can keep and recruit qualified and motivated personnel.

The Board of Directors have proposed that the term of the warrants shall be less than three years. The reason hereof is that the Board of Directors wishes to introduce an incentive program for employees and consultants in the Company and its subsidiaries with a term that corresponds to the term in the long-term incentive program 2021, which was decided by the extraordinary general meeting on October 5, 2021. The Board of Directors considers that it is of great value for the Company that participants in all of the Company’s incentive programs have the same structure and maturity on their respective instruments.

1.7 Preparation of the proposal
The basis for LTIP 2023:1 has been prepared by the Board of Directors of the Company. The work has been supported by external advisors and has been made in consultation with shareholders. The Board of Directors has thereafter decided to present this proposal for the general meeting. Except for the staff that have prepared the matter upon instruction from the Board of Directors, no employee that may be a Participant of the program has participated in the preparations of the program’s terms.

1.8 Majority requirements
The resolution by the general meeting regarding the implementation LTIP 2023:1 in accordance with the above requires that shareholders representing not less than nine-tenths of the votes cast as well as the shares represented at the general meeting approve the resolution.

Item 15 – Proposal on an incentive program to the board of directors
The shareholders Hawoc Investment AB and Sifonen AB (the “Proposers“), proposes that the general meeting pass a resolution on the implementation of a long-term incentive program 2023 (”LTIP 2023:2”) for current and acceding board members in Chordate Medical Holding AB (publ) (the ”Company”). The proposal is divided into the following items.

A. Resolution regarding issue and approval of transfer of warrants, series 2023/2025:2
B. Other matters in relation to LTIP 2023:2

A. Issue of warrants, series 2023/2025:2

The Proposers proposes that the general meeting resolve to carry out a private placement in respect of not more than 1,500,000 warrants of series 2023/2025:2, entailing an increase in the share capital of not more than SEK 375,000 if the private placement is fully taken up.

1. The resolution according to the above shall otherwise be governed by the following terms and conditions

1.1 The right to subscribe for the warrants, with derogation from the shareholders’ pre- emption rights, shall vest in the Company, with right and obligation to transfer the warrants to the current and acceding board members in the Company in accordance with below.

No oversubscription is allowed.

1.2 The reason for the derogation from the shareholders' pre-emption rights is that the Proposers wishes to implement an incentive program which provides current and acceding board members the opportunity to take part in the Company's long-term value development. The Proposers’ considers that the introduction of an incentive program promotes participation in the Company’s operations and creates the conditions to keep and recruit competent board members in the Company. A long- term ownership commitment through the incentive program is also expected to contribute to long-term value creation in the Company and to create a shared interest between the Company’s board members and its shareholders.

1.3 The warrants shall be issued at no consideration.

1.4 Subscription for the warrants shall take place on the same day as the date of the resolution to issue warrants. The Board of Directors shall be entitled to extend the subscription period.

1.5 Each warrant entitles the holder to subscribe for one new share in the Company.

1.6 The warrants may be exercised for subscription of new shares during the period commencing on November 1, 2025, up to and including November 30, 2025.

1.7 The subscription price per share shall correspond to 150 percent of the volume- weighted average price according to Nasdaq First North Growth Market’s official price list for the share during the ten trading days immediately preceding the Annual General Meeting.

1.8 Any share premium shall be transferred to the unrestricted premium reserve.

1.9 The shares subscribed for based on the warrants shall carry a right to participate in dividends for the first time on the next record date for dividends, which occurs after subscription is completed.

1.10 Other terms and conditions according to the complete terms and conditions for series 2023/2025:2.

2. Approval of transfer of warrants, series 2023/2025:2

2.1 The Proposers propose that the general meeting approves the Company’s transfer of warrants of series 2023/2025:2 in accordance with the following.

2.2 The right to acquire warrants from the Company shall vest in participant (the ”Participants”) in accordance with the table below.

Participants Number of warrants per
Participant
Chair and independent directors Max. 350,000
Other directors Max. 225,000

2.3 The warrants of series 2023/2025:2 shall be transferred on market terms at a price (premium) based on an estimated market value of the warrants that has been calculated by an independent valuation institute using the Black & Scholes valuation model.

2.4 The value for warrants of series 2023/2025:2 has, during March 2023, preliminary been calculated to SEK 0.05 per warrant based on a share price of SEK 0.53, a subscription price per share of SEK 0.80, a term of approximately 2.68 years, a risk-free interest rate of 2.8 percent and a volatility of 32 percent.

2.5 The final valuation of the warrants takes place in connection with the Participants' acquisition of the warrants and will be based on market conditions at that time.

2.6 Transfer to Participants requires that the warrants can be legally acquired and that, in the Board of Director’s opinion, such acquisition can take place using a reasonable amount of administrative and financial resources. Transfer to each Participant assume that such Participant enters into an agreement regarding, among other things, right of first refusal with the Company.

2.7 Application for acquisition of warrants shall take place on May 18, 2023. The Board of Directors is authorized to extend the application period.

2.8 Payment for warrants that are acquired must be made no later than on May 18, 2023. The board has the right to extend the time for payment.

2.9 The Company reserves the right to repurchase warrants if the assignment as board member for the Company ceases or if the Participant in turn wishes to transfer warrants. The warrants shall otherwise be governed by market terms.

2.10 Warrants held by the Company that are not transferred to Participants or that are repurchased from Participants, may be cancelled by the Company through a decision by the Board of Directors. The cancellation shall be notified to the Swedish Companies Registration Office.

B. Other matters in relation to LTIP 2023:2

1.1 Effects on key figures and costs
The Company’s earnings per share will not be affected by the issue, since the warrants’ strike price exceeds the current market value of the shares at the time of the issue. The Company’s future earnings per share may be affected by the potential dilutive effect of the warrants in the event the Company reports a positive result and the strike price is lower than the market value. The warrants will be transferred at market value, which means that no taxable benefit value will arise and thus no social fees for the Company. In addition, the warrant program will give rise to certain limited costs in the form of external consulting fees and administration of the warrant program.

1.2 Dilution of existing shares and votes
Based on the number of shares and votes outstanding in the Company, LTIP 2023:2 implies, upon exercise of all 1,500,000 warrants, a full dilution corresponding to approximately 0.64 percent of the total number of shares and votes outstanding in the Company on a fully diluted basis, however, subject to the recalculation of the number of shares that each warrant entitles to subscribe for that may occur as a result of certain issues etc.

Exercise of all warrants within the framework of all outstanding and proposed incentive programs in the Company would correspond to an aggregated dilution of approximately 4.52 percent of the total numbers of shares and votes in the Company on a fully diluted basis, however, subject to the recalculation of the number of shares that each warrant entitles to subscribe for that may occur as a result of certain issues etc.

1.3 Calculation of the market value
The market value has, during March 2023, preliminary been established based on a calculated market value for the warrants, applying the Black & Scholes valuation model calculated by Mazars Financial Advisory. The preliminary calculated market value is set out above in item A.2.4 above.

1.4 Other share-related incentive programs
In addition to the proposed incentive program for the management set out above in item 14, the Company’s share-related incentive programs are described on pages 25 and 29 in the company’s annual report.

1.5 Authorizations for the Board of Directors
The general meeting authorizes the Board of Directors to execute the resolution in item A.2. above. In addition, the Board of Directors, or a person appointed by the Board of Directors, shall be authorized to make minor adjustments to the resolutions above that may be necessary in connection with the registration with the Swedish Companies Registration Office and Euroclear Sweden AB, respectively.

1.6 The background and rationale for the proposal
The Proposers wishes to implement an incentive program which provides current and acceding board members the opportunity to take part in the Company's long- term value development. The Proposers’ considers that the introduction of an incentive program promotes participation in the Company’s operations and creates the conditions to keep and recruit competent board members in the Company. A long-term ownership commitment through the incentive program is also expected to contribute to long-term value creation in the Company and to create a shared interest between the Company’s board members and its shareholders.

The Proposers have proposed that the term of the warrants shall be less than three years. The reason hereof is that the Proposers wishes to introduce an incentive program for current and acceding board members in the Company with a term that corresponds to the term in the long-term incentive program 2021, which was decided by the extraordinary general meeting on October 5, 2021. The Proposers considers that it is of great value for the Company that participants in all of the

Company’s incentive programs have the same structure and maturity on their respective instruments.

1.7 Preparation of the proposal
The proposal on LTIP 2023:2 has been prepared by the Proposers. The work has been prepared by staff at the Company at the instruction of the Proposers and with support by external advisors. The Proposers has thereafter decided to present this proposal for the general meeting. No board member that may be a Participant of the program has participated in the preparation of the proposal.

1.8 Majority requirements
The resolution by the general meeting regarding the implementation LTIP 2023:2 in accordance with the above requires that shareholders representing not less than nine-tenths of the votes cast as well as the shares represented at the general meeting approve the resolution.

Miscellaneous
The board of directors and the CEO shall, if any shareholder so requests and the board of directors considers that it can be done without material harm to the company, provide information on matters that may affect the assessment of an item on the agenda and conditions that may affect the assessment of the company’s financial situation.

Copies of the annual financial report and the auditor’s report will be available at the company’s website, www.chordate.com, no later than two weeks prior to the general meeting. Copies of such documentation will be sent to shareholders who so requests and provides its address.

The total number of shares and votes of the company as per the date of this notice amounts to 232 416 507.

For the processing of personal data, please refer to the privacy policy available at the following link: https://www.euroclear.com/dam/ESw/Legal/Privacy-notice-bolagsstammor-engelska.pdf
_____________________
Chordate Medical Holding AB (publ)
the Board of Directors

Chordate Medical Holding AB publishes annual report for 2022

Chordate Medical Holding AB (Publ) has today published its annual report for 2022. The annual report is available on Chordate's website www.chordate.com and is attached to this press release.

The migraine market in Finland and Chordate’s outlook

Finland is one of the markets that Chordate Medical is focusing on to show proof of concept by gaining an evident market share with the K.O.S-treatment for chronic migraine. About 700,000 people in Finland suffer from migraines, and one in four of those completely lose their functional ability during migraine episodes, according to the Finnish Migraine Association.

The Finnish Social Insurance Institution (Kela) is responsible for social insurance and also reimburses some of the costs of visits and treatments from private care providers. Finland also has a unique occupational health care system where employers are obliged by law to provide preventive health care services to their employees. Most employers also choose to offer more healthcare services than the law requires. This has created a significant market for occupational health services in the country.

“Of course, Finland's system of statutory occupational health care for all employees is a factor that benefits us. Our long-term goal is to obtain reimbursement codes that allows patient insurance to cover the costs of the K.O.S-treatment, similar to what we have obtained in Saudi Arabia and partly in Italy,” says Anders Weilandt, CEO of Chordate.

Private healthcare providers in Finland
The Finnish health system is based on public health services to which all residents are entitled. There are many private health care providers in the country, providing over a quarter of all social and health care services. Two of the largest healthcare companies in Finland are Terveystalo and Mehiläinen.

Terveystalo provides hospital care for individuals, companies, insurance companies and the public sector. The company has 370 clinics in Finland, with approximately 25 of them operating in the field of neurology. Terveystalo's subsidiary Feelgood is Sweden's third largest occupational health care provider with approximately 8,000 corporate customers in Sweden.

Mehiläinen has over 2.1 million customers annually, of which approximately 590,000 are covered by occupational health services. The company has clinics and medical centres in about 500 locations around Finland, with about 70 active neurologists.

Chordate in Finland
In October 2022, Chordate began the market introduction in Finland through an agreement with a market consultant with extensive experience combined with a wide network of contacts. The Finnish market already has some knowledge of Chordate's migraine treatment as the company's recently completed migraine study was carried out at four clinics in Finland, three of which belong to Terveystalo.

“The study result and the fact that we have established knowledge in Finland is a bit of a dream scenario because it helps to legitimize the commercialization. In a market with private health insurance solutions, like the Finnish one, the path to decision is much shorter and more manageable for us compared to markets with only publicly funded health reimbursement models,” says Anders Weilandt, CEO of Chordate.

Chordate’s CEO Anders Weilandt presents at the Biostock Investor Meeting on March 16th – In English

Chordate Medical is one of the medtech companies participating at the Biostock Investor Meeting on March 16th. CEO Anders Weilandt will hold his presentation at 11:00 a.m. and talk about the company's focus in 2023 and beyond. After the presentation, he will answer questions in an interview. The presentation will be in English, and the interview will be held in Swedish.

Anders will, among other things, talk about the positive results from the recently completed migraine study, as well as the ongoing work to create proof-of-concept in the selected markets.

The event is streamed online on BioStock's website and YouTube channel.

Read more about the event

Chordate CEO Anders Weilandt to give presentation at Life Science Day on March 8th

Chordate Medical is one of the companies participating at this years’ Life Science Day in Gothenburg on March 8th. Chordate CEO Anders Weilandt will present the company and how K.O.S can become a global and valuable treatment option for people with chronic migraines.

The Life Science day takes place at the Wallenberg conference center next to Sahlgrenska in Gothenburg and consists of presentations by 15 companies active in the Life Science and Medtech sector, as well as professors and researchers.

The event is live streamed and can be seen afterwards at https://www.lifesciencedagen.se/

Year-End Report Chordate Medical Holding AB (publ) January – December 2022

Summary of the period October–December 2022

  • Net turnover was SEK 20,347 (403,257)
  • Cash flow from operating activities amounted to SEK -6,126,772 (-5,331,784)
  • Profit/loss after financial items was SEK -8,078,967 (-7,191,338)
  • Profit/loss after tax was SEK -8,078,967 (-7,191,338)
  • Earnings per share were SEK -0.05 (-0.05)

Summary of the period January–December 2022

  • Net turnover was SEK 108,517 (882,046)
  • Cash flow from operating activities amounted to SEK -24,979,043 (-20,336,340)
  • Profit/loss after financial items was SEK -27,942,965 (-21,766,276)
  • Profit/loss after tax was SEK -27,942,965 (-21,766,276)
  • Earnings per share were SEK -0.18 (-0.19)

COMMENTS FROM CEO ANDERS WEILANDT

MORE AND MORE PARTS FALL INTO PLACE IN THE STRATEGIC PLAN

When I look back at 2022, the obvious high point is that our migraine study was completed and undeniably demonstrates that K.O.S is an effective and safe alternative for preventive treatment of chronic migraine. This is the single most important milestone in Chordate’s history and marks that we have now entered the final phase in building value in the Company prior to a successful exit.

  • The migraine study has been delivered – strong significant results.
  • Agreements with market experts for introduction of K.O.S in Germany, Israel and Finland.
  • Agreement with one of Saudi Arabia’s leading medical device companies for neurology.
  • Reinforced cash position due to the outcome of the rights issue, which generated SEK 37.3 million before expenses in January 2023.

In 2023, focus will be on marketing and sales to deliver in accordance with the announced strategic plan. The goal is to show that we can build market shares on one or several of the selected markets (proof-of-concept) since this is a crucial step toward a successful exit for our shareholders.

New agreements set the stage for more market launches

During the second half of 2022, we took key steps forward with three new agreements with consultants for market penetration in Germany, Israel and Finland (and one agreement in the UK signed in February 2022). Equally important is the distributor agreement in December 2022 with Janin Medical Company in Saudi Arabia. Together with Janin and its existing position in the neurology segment, we can continue to move our K.O.S position forward in the region, and we are one step closer to proof of concept.

Complete results from the migraine study will be presented in the spring

In August 2022, we completed our crucial clinical study on chronic migraine. It would be hard to overemphasize the importance of the statistically significant results from the subgroup analysis that were announced in September. We have now delivered on what may be the most important of our interim goals for an exit, which already gives us access to the market with a sought-after alternative to medicinal treatment. Because it is important for the Company's value for the complete study to be published in a well-respected scientific journal, we must wait until such an article is approved for publication before we can announce the results in their entirety.

In addition, we are starting another two planned migraine studies. PM009 is an open pilot study to evaluate the efficacy of K.O.S in the preventive treatment of chronic migraine on patients not responding to treatment with CGRP inhibitors. This open pilot study is being conducted at King's College in London with three to four referring clinics assisting with recruitment of suitable subjects for the study. PM010 is an open clinical post-market surveillance study to follow long- term performance and safety of K.O.S in patients with chronic migraine during regular clinical treatment. The study will recruit 200 patients and be conducted at approximately 15 clinics in three to four European countries. The follow-up is 12 months.

Additional patent and continued work to receive marketing authorization in the USA

In June 2022, the US Patent Office granted our third US patent for headache treatment in the USA. The intellectual property rights defense for our technology as support for our continued business development is one of the Company’s core values. The project for marketing authorization for K.O.S from the US Food and Drug Administration (FDA) is progressing in parallel.

Marketing authorization for rhinitis indication in China

The project work with Nanos Medical for product registration of K.O.S in China continued in 2022, and the submission of an application for marketing authorization for the rhinitis indica- tion was started after the start of the new year. What is left in the project is fully dependent on the answer Nanos receives from the Chinese regulatory authority’s review work, so the scope cannot currently be assessed.

Financing

The rights issue conducted in December 2022 was subscribed to approximately 73 percent and raised approximately SEK 37.3 million for the Company before expenses. With the improved cash position, we can now finance the continued market and sales work. The show of support for the Company’s journey toward an exit from our shareholders is a clear rating of the strength of Chor- date’s offer, in particular given the current climate on the stock exchange and the state of the global economy. The implementation plan will naturally be adjusted by the outcome of the issue.

Focus 2023

  • Sales and marketing on select markets for proof of concept
  • Projects for marketing authorization in the USA and China
  • The studies PM009 and PM010

Kista, February 2023
Anders Weilandt, CEO

11 Italian clinics now offers the K.O.S treatment for chronic rhinitis

Chordate's Italian distributor Ve.Di.Se. Hospital S.P.A. now has installations offering K.O.S treatment for chronic rhinitis in eleven clinics around the country, from Tradate and Verona in the north to Bari in the south. At the same time, Vedise's work with the introduction of K.O.S also as a treatment for chronic migraine in Italy continues.

“K.O.S is now starting to establish itself as a medical treatment in Italy and we expect that the number of clinics offering K.O.S for chronic rhinitis will continue to increase. The standstill of almost two years that Covid19 caused in Italy was longer than in most markets, the accumulated healthcare backlog is still tangible. Vedise's long experience and large network of clinics are also of great value in their ongoing work to introduce K.O.S as a treatment for chronic migraine”, says Chordate CEO Anders Weilandt.

Chordate and Vedise began their collaboration at the end of 2018 when the parties signed an exclusive distribution partnership for Italy. The K.O.S treatment is now offered for chronic rhinitis in eleven clinics, and the plan is to increase the number of clinics further in 2023. Since August 2022, Vedise is investing large resources in being able to start offering K.O.S also for chronic migraine.

“The positive results from the migraine study have given further momentum to this project. Italy is an important market for us, partly because it’s one of Europe's largest medtech markets and partly because we expect that K.O.S will soon be offered both for chronic rhinitis and chronic migraine in the country. That makes Italy a strong example of proof-of-concept for us”.

Vedise is a well-established player in the Italian market, having supplied medical devices to public hospitals and private clinics for over 30 years. The distributor has a close collaboration with the medical profession.

Read more about Vedise Hospital: https://vedise.com/

See where Vedise offers K.O.S for chronic rhinitis in Italy: https://vedisekos.it/ (the eleventh clinic, located in Rome, is not yet marked on the map).