Chordate Medical presents interim report for Q2 2023

Chordate Medical Holding (publ) is releasing its interim report for Q2 2023 on Thursday, August 31, 2023, at 08:30. On Friday, September 1st, at 10:00, the company invites you to a webcast presentation of the report with CEO Anders Weilandt on Finwire TV.

The presentation can be viewed through the following link: https://www.finwire.tv/webcast/chordate-medical/q2-2023/

Following the presentation, there will be a Q&A session where viewers can submit questions.

A recording of the presentation will be made available afterwards on the company's website http://www.chordate.com and on Finwire TV's YouTube channel.

Chordate Medical presenterar delårsrapport för Q2 2023

Chordate Medical Holding (publ) offentliggör sin delårsrapport för Q2 2023 torsdag 31 augusti 2023 klockan 08:30. Fredag 1 september klockan 10:00 bjuder bolaget in till en webbsänd presentation av rapporten med vd Anders Weilandt på Finwire TV.

Presentationen kan ses via följande länk: https://www.finwire.tv/webcast/chordate-medical/q2-2023/

Efter presentationen följer en Q&A där det går att skicka in frågor.

En inspelning av presentationen kommer i efterhand finnas tillgänglig på bolagets hemsida www.chordate.com och på Finwire TV:s YouTube-kanal.

Manuscript with complete study results from migraine study submitted to scientific journal

The complete study results from Chordate Medical's migraine study 007 have today been submitted as a manuscript for publication in one of the three most prominent journals within the migraine field.

“This is a pivotal step, and once the scientific article is published, it will be a valuable tool for the company in marketing and sales efforts. Additionally, the article will be an important basis in upcoming reimbursement processes," says Anders Weilandt, CEO of Chordate Medical.

Chordate Medical will announce when the authors have received approval for publication in the journal in question.

The final results from Chordate Medical's PM007 study demonstrate that the company's migraine treatment, K.O.S, exhibits a significant reduction in the number of headache days and migraine days in adult patients with moderate to severe chronic migraine. The results also show that K.O.S maintains a sustained therapeutic effect and is well-tolerated, with few unexpected side effects. This sets apart the unique treatment, which is non-pharmaceutical, from other preventative treatments in the market, also due to its favorable side effect profile.

Manus med kompletta studieresultat från migränstudie inskickat till vetenskaplig tidskrift

Det kompletta studieresultatet från Chordate Medicals migränstudie 007 har av studieledarna idag skickats in som manus för publicering i en av de tre mest prominenta tidskrifterna inom migränområdet.

– Det här är ett avgörande steg och när den vetenskapliga artikeln har publicerats kommer det vara ett värdefullt verktyg för bolaget i marknads- och försäljningsarbetet. Artikeln blir dessutom ett viktigt underlag för kommande reimbursement-processer, säger Anders Weilandt, vd Chordate Medical.

Chordate Medical meddelar när författarna fått godkännande för publicering från tidskriften i fråga.

Slutresultaten från Chordate Medicals PM007-studie visar att bolagets migränbehandling K.O.S visar en signifikant minskning av antalet dagar med huvudvärk och dagar med migrän hos vuxna patienter med medelsvår och svår kronisk migrän. Resultaten visar även att K.O.S har en ihållande behandlingseffekt och att behandlingen tolereras väl med få oväntade biverkningar. Detta gör att den unika behandlingen, som inte är läkemedelsbaserad, skiljer sig från andra förebyggande behandlingar på marknaden också genom sin gynnsamma biverkningsprofil.

Chordate’s migraine study is presented at the IHC 2023 headache congress in Seoul

Chordate has been invited to present the K.O.S migraine treatment on the international stage, this time at the prestigious IHC 2023 congress, International Headache Congress, held in Seoul, Korea, from September 14-17, 2023. Dr. Hoffmann, one of the coordinating investigators for PM007, will present the results of the study on the K.O.S effect on individuals with chronic migraine in a poster presentation. Chordate will also be present as an exhibitor during the congress.

The IHC 2023 congress is organized every other year by the International Headache Society, IHS, in various locations around the world. This time, it is in Seoul, Korea, which is the first time the event has been held in Asia since 2005.

“The interest in the study and its results is significant within the migraine field. Being part of this congress is an excellent opportunity for us to inform about K.O.S as a treatment method to the absolute forefront of the migraine field worldwide," says Anders Weilandt, CEO of Chordate.

IHS is an international professional organization based in the UK that collaborates with others to benefit individuals affected by headache disorders. As a charity, the purpose of IHS is to advance headache science, education, and management, and to promote headache awareness worldwide.

More information about the congress: https://ihc2023.org/
More information about IHS: https://ihs-headache.org/en/

Chordates migränstudie presenteras på huvudvärkskongressen IHC 2023 i Seoul

Chordate har blivit inbjuden att presentera migränbehandlingen K.O.S på den internationella arenan, denna gång på den ansedda kongressen IHC 2023, International Headace Congress, som hålls i Seoul, Korea, 14-17 september 2023. Dr Hoffmann, en av de koordinerande studieledarna för PM007, kommer att i en poster-presentation redogöra för resultaten från studien om K.O.S effekt på individer med kronisk migrän. Chordate är också på plats som utställare under kongressen.

Kongressen IHC 2023 arrangeras vartannat år av International Headace Society, IHS, på olika platser i världen, denna gång i Seoul i Korea vilket är första gången eventet hålls i Asien sedan 2005.

– Intresset för studien och dess resultat är stort inom migränområdet, att vara med vid denna kongress är ett ypperligt tillfälle för oss att informera om K.O.S som behandlingsmetod till de absolut främsta inom migränfältet i världen, säger Anders Weilandt, vd Chordate.

IHS är en internationell professionell organisation baserad i Storbritannien som samarbetar med andra för att gynna personer drabbade av huvudvärksstörningar. Som en välgörenhetsorganisation är IHS:s syfte att främja huvudvärksvetenskap, utbildning och hantering samt att öka medvetenheten om huvudvärk över hela världen.

För mer information om kongressen: https://ihc2023.org/
För mer information om IHS: https://ihs-headache.org/en/

Fallbeskrivning från migränstudie presenteras i Berlin: kraftig minskning av migrändagar med hjälp av K.O.S

Under The German Migraine and Headache Societys kongress i Berlin presenterade dr Tim P. Jürgens en fallbeskrivning från Chordates migränstudie. Fallbeskrivningen redogör för en av patienterna i studien, en 45-årig kvinna, vars dagar med migrän minskade kraftigt, från 18 till 8 dagar per månad, med hjälp av K.O.S. Den positiva effekten av K.O.S-behandlingen varade i fyra månader utan ytterligare behandlingar.

– Fallbeskrivningen är ett bra exempel på en migränpatient som av olika anledningar inte kan medicinera med läkemedel som vanligtvis skrivs ut för kronisk migrän, och som upplever en väldigt positiv effekt av K.O.S. En minskning från 18 till 8 migrändagar per månad i kombination med fyra månaders ihållande effekt är ett betydande positivt resultat. Det visar på den stora potentialen med K.O.S som ett nytt behandlingsalternativ till människor som lider av kronisk migrän och som inte får effekt av andra befintliga behandlingar, säger Jan Hermansson, Clinical Research & Medical Director på Chordate Medical, som var på plats i Berlin.

Fallbeskrivningen är författad av Florian Rimmele tillsammans med Tim P. Jürgens och Peter Kropp vid Department of Neurology, Headache Center North-East, University Medical Center Rostock. Nedan följer ett utdrag från fallbeskrivningen:

A 45-year-old female patient with a long history of chronic migraine with visual auras presented to our headache center. In addition to systemic mastocytosis with evidence of a KIT-D816V mutation, the patient suffers from bronchial asthma, recurrent depression, and anxiety disorder. On average, the patient had migraine on 18 days/month. Due to mastocytosis and allergic reaction to multiple substances, acute medication was only possible with tramadol, which showed only moderate effect. The established medicinal migraine prophylactics could not be used because of various contraindications; the patient reacted allergically to the considered amitriptyline and also the multiple injections of a prophylaxis with onabotulinumtoxinA are contraindicated in mastocytosis.

The patient received kinetic oscillatory stimulation (K.O.S.) in a double-blind, randomized placebo-controlled trial. Over 6 weeks, weekly stimulation of 10 minutes per nostril was given, under which the migraine improved very well and a reduction to an average of 8 migraine days/month was achieved. The patient reported no side effects during the stimulation therapy. After completion of the study and unblinding, the patient could be assigned to the test (verum) group. The improvement effect lasted for 4 months.

Conclusion
In this particular case, established migraine prophylactic medication was not possible in a patient with chronic migraine, due to her other medical conditions, especially systemic mastocytosis. K.O.S., which was performed as part of a study, proved to be a well-tolerated and long-lasting prophylactic.

Case study from a migraine study presented in Berlin: significant reduction of migraine days with the help of K.O.S.

During The German Migraine and Headache Society's congress in Berlin, Dr. Tim P. Jürgens presented a case study from Chordate's migraine study. The case study accounts for one of the participating patients, a 45-year-old woman, whose days with migraines decreased significantly, from 18 to 8 days per month, with the help of K.O.S. The positive effect of the K.O.S. treatment lasted for four months without further treatment sessions.

“The case study is a good example of a migraine patient who, for various reasons, cannot medicate with drugs typically prescribed for chronic migraines, and who experiences a very positive effect from K.O.S. A reduction from 18 to 8 migraine days per month, combined with a four-month sustained effect, is a significant positive outcome. It demonstrates the great potential of K.O.S. as a new treatment option for individuals suffering from chronic migraines and who do not respond to other existing treatments," says Jan Hermansson, Clinical Research & Medical Director at Chordate Medical, who was present in Berlin.

The case study was authored by Florian Rimmele together with Tim P. Jürgens and Peter Kropp at the Department of Neurology, Headache Center North-East, University Medical Center Rostock. Below is an excerpt from the case study:

A 45-year-old female patient with a long history of chronic migraine with visual auras presented to our headache center. In addition to systemic mastocytosis with evidence of a KIT-D816V mutation, the patient suffers from bronchial asthma, recurrent depression, and anxiety disorder. On average, the patient had migraine on 18 days/month. Due to mastocytosis and allergic reaction to multiple substances, acute medication was only possible with tramadol, which showed only moderate effect. The established medicinal migraine prophylactics could not be used because of various contraindications; the patient reacted allergically to the considered amitriptyline and also the multiple injections of a prophylaxis with onabotulinumtoxinA are contraindicated in mastocytosis.

The patient received kinetic oscillatory stimulation (K.O.S.) in a double-blind, randomized placebo-controlled trial. Over 6 weeks, weekly stimulation of 10 minutes per nostril was given, under which the migraine improved very well and a reduction to an average of 8 migraine days/month was achieved. The patient reported no side effects during the stimulation therapy. After completion of the study and unblinding, the patient could be assigned to the test (verum) group. The improvement effect lasted for 4 months.

Conclusion
In this particular case, established migraine prophylactic medication was not possible in a patient with chronic migraine, due to her other medical conditions, especially systemic mastocytosis. K.O.S., which was performed as part of a study, proved to be a well-tolerated and long-lasting prophylactic.

Chordates migränstudie presenteras på huvudvärkskongress i Berlin

Efter att resultaten från Chordate Medicals migränstudie PM007 presenterades för första gången på American Headache Society Scientific Meeting, kommer medförfattaren dr Charly Gaul från Headache Center Frankfurt presentera studien på The German Migraine and Headache Societys kongress i Berlin 30 juni. Chordate Medicals Clinical Research & Medical Director Jan Hermansson kommer vara på plats i Berlin där bolaget ställer ut tillsammans med den tyska marknadspartnern MTIGER GmbH.

– Intresset för studien och dess resultat är stort inom migränområdet och det är en bra möjlighet för oss att informera om K.O.S som behandlingsmetod. Tyskland är en av bolagets prioriterade marknader och vår samarbetspartner MTIGER GmbH har kommit en bra bit på vägen med arbetet att introducera K.O.S-behandlingen till marknad- och opinionsledande neurologer i landet, säger Anders Weilandt, vd Chordate.

The German Migraine and Headache Society (DMKG) grundades 1979 av en grupp forskare och har idag mer än 450 medlemmar, främst neurologer, anestesiläkare och allmänläkare, samt psykologer och farmakologer. Ett av organisationens syften är att Förbättra behandlingsmöjligheter för patienter med akut och kronisk huvudvärk.

Chordate’s migraine study will be presented at headache congress in Berlin

After the results of Chordate Medical's migraine study PM007 were first presented at the American Headache Society Scientific Meeting, co-author Dr. Charly Gaul from the Headache Center Frankfurt will present the study at The German Migraine and Headache Society's congress in Berlin on June 30th. Chordate Medical's Clinical Research & Medical Director, Jan Hermansson, will be present in Berlin, where the company will participate in an exhibition alongside its German partner, MTIGER GmbH.

“The interest in the study and its results is significant within the migraine field, and this is a great opportunity for us to inform about K.O.S as a treatment method. Germany is one of the Chordate’s prioritized markets, and our partner, MTIGER GmbH, has made significant progress in introducing the K.O.S treatment to key neurologists and opinion leaders in the country," says Anders Weilandt, CEO of Chordate.

The German Migraine and Headache Society (DMKG) was founded in 1979 by a group of dedicated headache scientists and today has more than 450 members, mainly Neurologists, Anaesthetists and General Practitioners, as well as Psychologists and Pharmacologists. One of the organization's goals is to improve treatment options for patients with acute and chronic headaches.